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Online Advanced Release
Articles appearing in this "Online Advanced Release" section have been peer-reviewed and accepted for publication in the Journal of Refractive Surgery and posted online before print publication. Articles appear on this site after copyediting and author corrections, but before final proofing. The content of the article will usually remain unchanged, and possible further corrections are fairly minor. The final published article will specify the issue and page numbers. Once the final version is available in print, the version posted here will be removed from this site.
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Table of Contents
Salomon Esquenazi, MD; Isi Esquenazi; Lev Grunstein, MD; Juicheng He, MD, PhD; Haydee Bazan, PhD
Submitted: 12/14/07; Accepted: 8/15/08; Posted: 9/30/08In five corneas that developed ectasia after LASIK and underwent penetrating keratoplasty, the LASIK flap showed a corneal scar with myofibroblasts, increased chondroitin sulfate in the wound, and positive staining for matrix metalloproteinase 9 in the area of the wound margin scar.
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Kyaw Lin Tu, FRCSE; Ioannis M. Aslanides, MD, PhD, MBA
Submitted: 5/23/08; Accepted: 8/15/08; Posted: 9/30/08Corneal collagen cross-linking in eyes with keratoconus can have different effects on topography depending on the preoperative pattern of keratoconus. A preoperative central cone may flatten after cross-linking whereas an eccentric cone preoperatively may steepen centrally after cross-linking.
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Ella G. Faktorovich, MD; Emily Nosova, BA
Submitted: 6/9/07; Accepted: 8/7/08; Posted: 9/30/08In a series of eight eyes that received LASIK that had loose epithelium at the time of the initial LASIK surgery, residual epithelial basement membrane degeneration and a small amount of emmetropia remained. Epithelial removal and 30 excimer laser pulses of phototherapeutic keratectomy spread over a large area were delivered. There was improvement in uncorrected visual acuity in all eyes with some decrease in refractive error.
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Dan Z. Reinstein, MD, MA(Cantab), FRCSC, FRCOphth; Timothy J. Archer, MA(Oxon), DipCompSci(Cantab); Marine Gobbe, MST(Optom), PhD; Ronald H. Silverman, PhD; D. Jackson Coleman, MD
Submitted: 1/10/08; Accepted: 8/5/08; Posted: 9/30/08Stromal thickness profile was characterized in a series of normal eyes to represent a normative data set, which may help in early diagnosis of corneal abnormalities such as keratoconus. Absolute stromal thickness progression was independent of stromal thickness.
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Endothelial Decompensation Following Epithelial LASIK With Loss of Epithelial Flap
Sameer Kaushal, MD; Gaurav Prakash, MD; Namrata Sharma, MD; Jeewan S. Titiyal, MD
Submitted: 11/3/07; Accepted: 7/29/08; Posted: 9/30/08Endothelial decompensation after bilateral epithelial LASIK was noted in the right eye of a patient with no preoperative features suggestive of pre-existing endothelial dysfunction, but not in the left eye treated similarly.
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Circular Keratotomy to Reduce Astigmatism and Improve Vision in Stage I and II Keratoconus
Jorg H. Krumeich, MD; Guy M. Kezirian, MD, FACS
Submitted: 8/28/07; Accepted: 7/11/08; Posted: 9/30/08Circular keratotomy with a running suture for stage I and II keratoconus significantly reduced corneal astigmatism and improved best spectacle-corrected visual acuity in a retrospective analysis of 46 eyes operated from 1993 to 2006. Eyes with greater amounts of preoperative astigmatism benefited most.
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Nicola Rosa, MD; Luigi Capasso, MD, PhD; Michele Lanza, MD; Maria Borrelli, MD
Submitted: 2/5/08; Accepted: 7/29/08; Posted: 9/15/08In a series of 62 eyes that previously underwent corneal refractive surgery, intraocular lens power needed for cataract surgery was calculated using an axial length-related corneal radius correcting factor. The refractive outcomes ranged between –3.25 and +1.00 D, with 60% of eyes within ±0.50 D of the intended refraction.
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Luca Buzzonetti, MD; Gianni Petrocelli, MD; Antonio Laborante, MD; Emilio Mazzilli, MD; Mario Gaspari, MD; Paola Valente, MD
Submitted: 3/11/08; Accepted: 7/29/08; Posted: 9/15/08Arcuate keratotomy performed using the IntraLase femtosecond laser in nine patients with high astigmatism after penetrating keratoplasty reduced the mean refractive astigmatism from 9.00 to 3.00 D.
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Maria Clara Arbelaez, MD; Camila Vidal, OD; Samuel Arba Mosquera, MSc
Submitted: 1/8/08; Accepted: 7/29/08; Posted: 9/15/08Central ablation depth after myopic LASIK was measured using ultrasound, Scheimpflug, and optical coherence pachymetry and correlated with postoperative refraction. Differential pachymetry correlated to intended central ablation depth for all techniques, whereas none of the techniques were effective in predicting the achieved refractive change.
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Toric Intraocular Lenses-Theory, Matrix Calculations, and Clinical Practice
Achim Langenbucher, PhD; Anja Viestenz, MD, FICO; Nóra Szentmáry, MD, PhD; Wolfgang Behrens-Baumann, MD; Arne Viestenz, MD, FICO
Submitted: 4/9/08; Accepted: 7/29/08; Posted: 9/15/08Formulas and metrics for determining intraocular lens power and residual refraction after toric IOL implantation are reviewed. Clinical recommendations are provided.
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Aldo Caporossi, MD, PhD; Fabrizio Casprini, MD, PhD; Gianluca Martone, MD; Angelo Balestrazzi, MD, PhD; Gian Marco Tosi, MD, PhD; Leonardo Ciompi, MD
Submitted: 3/4/08; Accepted: 7/8/08; Posted: 9/15/08In a series of 100 patients with bilateral cataracts, the quality of vision with aspheric compared to spherical intraocular lenses was studied after 2-year follow-up. Implantation of a modified aspheric IOL improves functional visual performance by reducing total spherical aberration and improving contrast sensitivity.
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Objective Evaluation of the Visual Benefit in Contact Lens Fitting After Complicated LASIK
César Villa-Collar, OD, MSc; José Manuel González-Méijome, OD, PhD; Ramón Gutiérrez-Ortega, MD, PhD
Submitted: 10/2/07; Accepted: 7/8/08; Posted: 9/15/08Four patients with poor vision after refractive surgery were treated with different contact lens fitting approaches and objectively monitored to quantify the visual improvements provided by the contact lenses. The visual benefit was measured through luminous distortion under scotopic conditions.
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Estimation of Posterior Corneal Power for IOL Calculation After Myopic LASIK
Sabong Srivannaboon, MD; Thanapat Rakpanichmanee, MD; Arthur C.K. Cheng, MRCS, FCOphth(HK); Han-Bor Fam, MD
Submitted: 5/5/07; Accepted: 7/2/08; Posted: 9/15/08This retrospective series of 50 patients (92 eyes) provides an alternative method of estimating posterior corneal power for IOL calculation after myopic LASIK using a formula computed from postoperative Sim K, central corneal thickness, and the amount of myopia treated.
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Michael C. Knorz, MD; Urs Vossmerbaeumer, MD
Submitted: 2/26/08; Accepted: 7/8/08; Posted: 8/29/08In a series of rabbits, the 150 kHz IntraLase laser with an inverted side-cut created a stronger adhesion than the Amadeus II microkeratome at 10 weeks after surgery.
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Dan Z. Reinstein, MD, MA(Cantab), FRCSC, DABO, FRCOphth; Timothy J. Archer, MA(Oxon), DipCompSci(Cantab); Marine Gobbe, MST(Optom), PhD
Submitted: 7/27/07; Accepted: 7/8/08; Posted: 8/29/08In a series of 48 eyes with complications after LASIK or PRK, the Carl Zeiss Meditec platform was used to combine manifest refraction, corneal wavefront data, and corneal topography to treat the corneal irregularity and refractive error, with improvement in both parameters.
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Nancy J. Keir, OD, PhD; Trefford Simpson, PhD; Lyndon W. Jones, PhD, FAAO; Desmond Fonn, MOptom, FAAO
Submitted: 4/7/07; Accepted: 7/3/08; Posted: 8/29/08In a prospective trial of bilateral LASIK in 162 myopic patients with a manifest sphere refraction from -0.25 to -6.50 D, wavefront-guided treatments were carried out with the LADARVision4000 platform. At 6 months postoperative, photopic contrast sensitivity improved at 3, 6, and 12 cpd, and there was no change in higher order spherical aberration.
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LASIK for Myopia Using the Zeiss VisuMax Femtosecond Laser and MEL 80 Excimer Laser
Marcus Blum, MD; Kathleen Kunert, MD; Annika Gille; Walter Sekundo, MD
Submitted: 5/31/07; Accepted: 6/10/08; Posted: 8/15/08In a series of 32 eyes using the Carl Zeiss Meditec femtosecond laser and MEL 80 excimer laser, 94% of eyes were within ±0.50 D of intended and 91% saw 20/20 or better uncorrected at 3 months. At the 20/16 and 20/20 level, eyes after LASIK saw better than the same eyes with spectacle correction preoperatively.
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Sung Chul Park, MD; Young Kyo Kwun, MD; Eui-Sang Chung, MD, PhD; Kyeon Ahn, MD; Tae-Young Chung, MD, PhD
Submitted: 3/16/08; Accepted: 6/18/08; Posted: 8/15/08In a series of 30 consecutive eyes that received the STAAR Toric Implantable Collamer Lens for myopic astigmatism, no significant rotation or footplate displacement were detected during mean follow-up of 7.6 months.
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Detlef Uthoff, MD, FSES, FABI; Detlef Holland, MD; Daniel Hepper; Amit Gulati, PhD; Lioba Koch, OD; Wolfgang Haigis, MS, PhD
Submitted: 7/17/06; Accepted: 6/10/08; Posted: 8/15/08Using the Zeiss ACMaster laser interferometer, movement of the 1CU potential accommodating IOL was measured in 15 human eyes, showing movement consistent with an accommodative effect of less than 0.50 D, both with optical and pilocarpine stimulation.
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Comparison of the VISX WaveScan and NIDEK OPD-Scan Aberrometers
David Sungmin Kim, BS; Julio Narváez, MD; Jabin Krassin, MD; Khaled Bahjri, MD, MPH
Submitted: 8/21/07; Accepted: 6/13/08; Posted: 7/31/08In a series of 92 eyes that had lower and higher order optical aberrations measured by the VISX WaveScan and the NIDEK OPD aberrometers, significant and clinically meaningful differences existed between the two instruments.
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Takushi Kawamorita, CO, PhD; Nanami Nakayama, CO, MSc; Hiroshi Uozato, PhD
Submitted: 4/18/07; Accepted: 6/20/08; Posted: 7/31/08In a series of normal eyes, the corneal power readings with the Pentacam rotating Scheimpflug camera slit-light for central curvature were statistically significantly different than those from the Keratron Placido-disk.
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Corneal Molecular and Cellular Biology Update for the Refractive Surgeon
Marcella Q. Salomao, MD; Steven E. Wilson, MD
Submitted: 3/31/08; Accepted: 6/26/08; Posted: 7/31/08Review of wound healing differences between LASIK with a microkeratome and femtosecond laser, haze generation and resolution, and the effect of mitomycin C on corneal morphology after surface ablation.
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Multiple Component Intraocular Lens: First Human Implantation
Hendrik A. Fuchs, MD; Andreas Frohn, MD; Kevin Dean; Michael Alzubaydi; Theodore P. Werblin, MD, PhD, PC
Submitted: 11/27/07; Accepted: 6/4/08; Posted: 7/31/08First human implantation of the foldable version of the multi-component IOL implanted through a <3-mm incision in a 62-year-old woman. Postoperative visual acuity was 20/20.
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Takefumi Yamaguchi, MD; Kazuno Negishi, MD; Dogru Murat, MD; Megumi Saiki, CO; Kazuo Tsubota, MD
Submitted: 4/19/08; Accepted: 6/11/08; Posted: 7/31/08In 10 consecutive patients with cataracts who had a best spectacle-corrected visual acuity of 20/20 or better and who had uneventful phacoemulsification surgery with IOL implantation, the NIDEK functional visual acuity measurement system demonstrated significant improvements postoperatively.
[Read more]
Agreement Between Pentacam and Videokeratography in Corneal Power Assessment
Giacomo Savini, MD; Piero Barboni, MD; Michele Carbonelli, MD; Kenneth J. Hoffer, MD, FACS
Submitted: 3/15/08; Accepted: 6/20/08; Posted: 7/31/08In a series of normal eyes, the Pentacam corneal power findings were compared to those of the TMS-2 and in a separate series the Keratron Scout. The values are clinically meaningfully different, and cannot be used interchangeably. The true net power of the Pentacam cannot be entered into intraocular lens power formulas.
[Read more]
Presbyopia Treatment by Monocular Peripheral PresbyLASIK
Robert Leonard Epstein, MD, MSEE; Mark Andrew Gurgos, COA
Submitted: 7/4/07; Accepted: 6/18/08; Posted: 7/31/08At a mean of approximately 2 years postoperatively, 91% of 103 patients who received monocular peripheral presbyLASIK reported complete spectacle independence.
[Read more]
Precision of Orbscan II Assessment of Anterior Corneal Curvature and Asphericity
William Arthur Douthwaite, PhD; Annette Parkinson, BSc
Submitted: 10/24/07; Accepted: 6/10/08; Posted: 7/31/08Three measurements were adequate to determine the precision of the Orbscan II corneal curvature measurements, which were most consistent when done in a single meridian.
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Ultraviolet Femtosecond Laser Creation of Corneal Flap
Ronan Le Harzic, PhD; Karsten König, PhD; Christian Wüllner, Ing; Klaus Vogler, PhD; Christof Donitzky, Ing
Submitted: 6/27/07; Accepted: 6/10/08; Posted: 7/31/08A solid-state ultraviolet femtosecond laser with a wavelength of 345 nm was able to create 100-µm-thick flaps on porcine eyes.
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Diego de Ortueta, MD, FEBO; Samuel Arba Mosquera, MSc; Holger Baatz, MD, FEBO
Submitted: 9/15/07; Accepted: 5/6/08; Posted: 7/31/08Induced corneal wavefront aberrations were compared among myopic eyes treated by LASIK with the SCHWIND ESIRIS platform using an aspheric aberration neutral ablation profile versus a classic Munnerlyn standard profile. Both groups had good predictability and safety results, with the aberration neutral group resulting in less corneal wavefront aberration.
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Jerome C. Ramos-Esteban, MD; Sonya Bamba, MD; Ronald R. Krueger, MD, MSE
Submitted: 8/21/07; Accepted: 6/13/08; Posted: 7/31/08LASIK surgery was delayed in five patients with darkly pigmented irides, which may aid in reducing light scatter so that eye tracking can be achieved.
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Urrets-Zavalia Syndrome Following Iris-Claw Phakic Intraocular Lens Implantation
Shin Hae Park, MD; So Youl Kim, MD; Hyung Il Kim, MD; Suk Woo Yang, MD, PhD
Submitted: 6/19/08; Accepted: 6/26/08; Posted: 7/31/08Urrets-Zavalia syndrome, unrelated to intraocular pressure elevation, occurred in a 27-year-old woman after uneventful phakic IOL implanation.
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Sang Woo Kim, MD; Eung Kweon Kim, MD, PhD; Beom-Jin Cho, MD; Sun Woong Kim, MD; Ki Yung Song, MD; Tae-im Kim, MD
Submitted: 7/10/07; Accepted: 4/16/08; Posted 7/15/08The exact central corneal power value in the Pentacam true net power map can be used as the keratometric power in the SRK/T formula to calculate intraocular lens power in eyes with previous refractive corneal surgery, yielding a postoperative refraction within ±0.50 D for 70% of eyes.
[Read more]
Factors Affecting Vaulting After Implantable Collamer Lens Implantation
Kazutaka Kamiya, MD, PhD; Kimiya Shimizu, MD, PhD; Mari Komatsu, MD, PhD
Submitted: 7/3/07; Accepted: 4/4/08; Posted: 7/15/08In a series of 123 eyes undergoing STAAR Implantable Collamer Lens (ICL) implantation, younger patients and eyes with greater white-to-white distances were more likely to have higher ICL vaulting over the crystalline lens.
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Jacob Reznik, MD; James J. Salz, MD; Alena Klimava, MS
Submitted: 8/7/06; Accepted: 5/9/08; Posted: 7/15/08The authors present a patient with abnormal preoperative topography who developed clinically significant progression of corneal ectasia after PRK.
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Donald R. Sanders, MD, PhD; David A. Bernitsky, MD; Paul J. Harton, Jr, MD; Robert P. Rivera, MD
Submitted: 12/10/07; Accepted: 6/10/08; Posted: 7/15/08A correction factor was deemed unnecessary in IOL power calculation based on the presence of an ICL, as measurements of pre- and postoperative axial lengths using the Zeiss IOLMaster resulted in a <0.1-mm error.
[Read more]
Danielle Z. Savitsky, BA; Vincent C. Fan, MD; Elvin H. Yildiz, MD; Ted T. Du, MD; Penny A. Asbell, MD
Submitted: 10/5/07; Accepted: 5/8/08; Posted: 7/15/08Using reverse geometry contact lenses to flatten the cornea and treat myopia, corneal refractive therapy does not increase corneal epithelial permeability to fluoroscein.
[Read more]
Tae-Young Chung, MD; Sung Chul Park, MD; Myoung Ok Lee, MD; Kyeon Ahn, MD; Eui-Sang Chung, MD, PhD
Submitted: 9/4/07; Accepted: 4/1/08; Posted: 6/30/08In a series of 48 eyes that received the STAAR Implantable Collamer phakic intraocular lens and followed for a mean of 33 months, there was an immediate postoperative 40% narrowing of the anterior chamber angle that was not progressive over time. There was no increase in angle pigmentation or intraocular pressure over time, except for 1 eye that required antiglaucoma medication.
[Read more]
Pei-Yuang Su, MD; Fung-Rong Hu, MD
Submitted: 11/7/07; Accepted: 4/18/08; Posted: 6/30/08Comparing the Tecnis Z9000 aspheric IOL and the AcrySof SA60AT spherical IOL in right or left eyes of the same individual, the Tecnis showed statistically significantly lower total higher order aberrations and lower spherical aberration, but there was no difference in the spectacle-corrected visual acuity, mean pupil size, or contrast sensitivity.
[Read more]
Ryo Kosaki, MD; Naoyuki Maeda, MD; Hitoshi Hayashi, MD; Takashi Fujikado, MD; Shigeki Okamoto, MD
Submitted: 10/18/06; Accepted: 4/24/08; Posted: 6/30/08LASIK was performed in a series of 22 eyes with the NIDEK EC-5000CXII laser and Optimized Aspheric Transition zone (OATz) and compared to a non-randomized group of 11 eyes with conventional ablation pattern. The increase in total higher order aberration for conventional ablation was 0.7 µm and 0.51 µm for OATz; the increase in spherical aberration was 0.38 µm for conventional ablation and 0.22 µm for OATz. The OATz algorithm induced less optical aberrations than conventional.
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Measurement of Depth of Intacs Implanted Via Femtosecond Laser Using Pentacam
Günhal Kamburoglu, MD; Aylin Ertan, MD; Osman Saraçbasi, PhD
Submitted: 11/28/07; Accepted: 5/6/08; Posted: 6/30/08Thirty-two eyes with keratoconus received Intacs corneal ring segments in channels created by a femtosecond laser. At 1 year after surgery, the Pentacam showed the channel depth to be deeper than intended by 6.4 to 69.0 µm. Between 1 week and 1 year, the segments showed a decrease in depth of approximately 10 µm on the average.
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Efekan Coskunseven, MD; Mirko R. Jankov II, MD, PhD; Farhad Hafezi, MD, PhD
Submitted: 9/2/07; Accepted: 5/8/08; Posted: 6/30/08In a series of 19 patients with keratoconus, the more advanced eye was treated with collagen cross-linking and the less advanced eye served as a control. Nine months after treatment, the maximum keratometric power in the treated eyes had decreased by a mean of 1.50 D whereas in the control eyes it was unchanged.
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Subconjunctival Gas Bubble Formation During LASIK Flap Creation Using Femtosecond Laser
Takeshi Ide, MD, PhD; George D. Kymionis, MD, PhD; David A. Goldman, MD; Sonia H. Yoo, MD; Terrence P. O'Brien, MD
Submitted: 11/28/07; Accepted: 5/8/08; Posted: 6/13/08Subconjunctival bubble formation occurred during LASIK flap creation with the IntraLase femtosecond laser.
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J. Bradley Randleman, MD; Alfred J. White, Jr, BS; Michael J. Lynn, MS; Michelle H. Hu, BA; R. Doyle Stulting, MD, PhD
Submitted: 2/8/08; Accepted: 4/16/08; Posted: 6/13/08In a retrospective review of 855 eyes that underwent LASIK or PRK with the WaveLight ALLEGRETTO WAVE excimer laser using the wavefront optimized program, retreatment rate was 6.3%, and was not influenced by procedure technique, amount of myopia, patient age, or other tested variables. However, retreatment rates were higher with hyperopia and astigmatism >1.00 D.
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Rosario G. Anera, PhD; César Villa, OD; José R. Jiménez, PhD; Ramón Gutierrez, PhD
Submitted: 5/25/07; Accepted: 4/1/08; Posted: 6/13/08Contact lens corneal refractive therapy (orthokeratology) increased higher order aberrations and decreased contrast sensitivity function more than LASIK for eyes with a mean spherical refractive error of approximately –2.00 D.
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Seven-year Follow-up of LASIK for Myopia
Waldir Neira Zalentein, MD; Timo M.T. Tervo, MD; Juha M. Holopainen, MD
Submitted: 8/23/07; Accepted: 4/1/08; Posted: 6/13/08In a retrospective series of 38 eyes followed for 7 years or more after LASIK, a regression toward myopia of approximately 1.00 diopter and of undetermined origin occurred over 7 years. Corneal ectasia was not encountered.
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Byoung Jin Ha, MD; Sun Woong Kim, MD; Sang Woo Kim, MD; Eung Kweon Kim, MD, PhD; Tae-im Kim, MD
Submitted: 9/5/07; Accepted: 3/25/08; Posted 6/13/08In a retrospective study of 60 eyes, Pentacam showed insignificant change in posterior corneal curvature before and after PRK, whereas Orbscan II showed central elevation after PRK.
[Read more]
Stefanie Knapp, MD; Shady T. Awwad, MD; Claudine Ghali, RN; James P. McCulley, MD
Submitted: 8/14/07; Accepted: 3/25/08; Posted: 6/13/08The Fourier-based WaveScan aberrometer and Zernike-based LADARWave aberrometer compared optical aberrations in 36 normal and 10 postoperative LASIK eyes. Similar values were obtained for higher order aberrations; 11% had similar spherical aberration, 31% similar coma, and 33% similar trefoil values.
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Alaa M. El Danasoury, MD, FRCS; Tamer O. Gamaly, MD, FRCS; Mohamed Hantera, MD, FRCS
Submitted: 1/29/07; Accepted: 3/25/08; Posted: 6/13/08Using the NIDEK EC-5000 laser in a multizone pattern to create center-distance and paracentral-near vision to treat presbyopia in 146 eyes of patients followed for 1 year, approximately 50% were rendered spectacle-free. The hyperopic group was more satisfied than the myopic group.
[Read more]
Dan Z. Reinstein, MD, MA(Cantab), FRCSC, FRCOphth; Timothy J. Archer, MA(Oxon), DipCompSci(Cantab); Ronald H. Silverman, PhD; Mark J. Rondeau; D. Jackson Coleman, MD
Submitted: 7/24/07; Accepted 3/12/08; Posted: 6/13/08In a series of 40 eyes studied with Artemis 1 very high-frequency digital ultrasound to measure anterior chamber angle and ciliary sulcus diameters and with Orbscan to measure horizontal white-to-white corneal diameters, the angle and sulcus diameters were approximately the same and the white-to-white measurement was approximately 1.0 mm (SD 0.28 mm) smaller than the residual angle diameter.
[Read more]
Aberration-neutral Ablation Pattern in Hyperopic LASIK With the ESIRIS Laser Platform
Diego de Ortueta, MD, FEBO; Samuel Arba-Mosquera, MSc; Holger Baatz, MD, FEBO
Submitted: 12/18/07; Accepted: 3/12/08; Posted: 6/13/08In a retrospective series of 33 eyes that underwent hyperopic LASIK with the SCHWIND Aberration-Free™ (aberration-neutral) laser platform, the induced corneal aberrations were less than those calculated with the classical profile.
[Read more]
Prophylaxis of Diffuse Lamellar Keratitis With Intraoperative Interface Steroids in LASIK
Eugene Y. J. Ng, MD; Sashin Thinagaran, MD; Frank Kinsella, MD; Michael O'Keefe, MD
Submitted: 11/26/07; Accepted: 3/25/08; Posted: 5/30/08In a series of 605 eyes that received intraoperative interface steroids during LASIK compared to a series of 605 eyes done prior to that intervention without interface steroids, the prevalence of isolated, non-clustered DLK was markedly decreased from approximately 6% in controls to 1% in treated eyes.
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Kazutaka Kamiya, MD, PhD; Kimiya Shimizu, MD, PhD; Wakako Ando, COT; Yoshimori Asato, MD, PhD; Tadatoshi Fujisawa, MD, PhD
Submitted: 8/27/07; Accepted: 5/6/08; Posted: 5/30/08Two patients with a history of contact lens intolerance underwent successful implantation of the STAAR phakic toric ICL for the correction of high myopic astigmatism with stable keratoconus.
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Neal A. Sher, MD, FACS; Mikhail P. Golben, BS; William Bond, MD; William B. Trattler, MD; Shachar Tauber, MD; Terry G. Voirin, DO
Submitted: 6/8/07; Accepted: 3/25/08; Posted: 5/30/08In a prospectively randomized trial, patients having standard PRK received Acular LS four times a day or Xibrom twice a day. There was no difference in pain, burning, photophobia, or foreign body sensation during the four days postoperatively. Cold BSS and a therapeutic contact lens were used in all eyes.
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Arthur C. K. Cheng, MRCS, FCOphth(HK); Thomas Ho, MRCS; Silvania Lau, BSc; Dennis S. C. Lam, FRCS, FRCOphth
Submitted: 2/26/07; Accepted: 3/25/08; Posted: 5/30/08Using Orbscan II to measure posterior corneal curvature after LASIK results in an apparent steepening, which is sometimes interpreted as ectasia. Using mathematical simulation and clinical cases, the authors demonstrate that the posterior corneal curvature remains the same before and after LASIK.
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Dan Z. Reinstein, MD, MA(Cantab), FRCSC, FRCOphth; Darren G. Couch, BScOptom; Timothy J. Archer, MA(Oxon), DipCompSci(Cantab)
Submitted: 7/5/07; Accepted: 3/7/08; Posted: 5/30/08In a series of 258 hyperopic eyes with a spherical equivalent refraction ranging from +0.25 to +5.75 D, monovision was treated using the Zeiss MEL80 platform with the distance eye set for plano and the near eye set for -1.00 to -1.50 D regardless of age. With mean 1-year follow-up, binocularly, 95% of patients achieved 20/20 or better and could read J5 or smaller.
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Aspheric Intraocular Lens Selection Based on Corneal Wavefront
Mark Packer, MD, FACS; I. Howard Fine, MD; Richard S. Hoffman, MD
Submitted: 8/20/07; Accepted: 1/30/08; Posted: 5/30/08The authors mask preoperative corneal spherical aberration with intraocular lenses used for cataract surgery that had different spherical aberration corrections: the AMO Tecnis, Alcon Acrysof IQ, and B & L SofPort AO. They reduced whole eye spherical aberration from a mean preoperative corneal spherical aberration of +0.26 to a mean postoperative spherical aberration of –0.013.
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Factors Affecting Contrast Sensitivity With the Artisan Phakic Intraocular Lens for High Myopia
Takefumi Yamaguchi, MD; Kazuno Negishi, MD; Naoko Kato, MD; Hiroyuki Arai, MD; Ikuko Toda, MD; Kazuo Tsubota, MD
Submitted: 7/23/07; Accepted: 1/16/08; Posted: 5/30/08In a series of 60 eyes with the Artisan phakic intraocular lens for myopia from –6.75 to –23.75 D with 3-month follow-up, contrast sensitivity without glare was the same before and after surgery; contrast sensitivity with glare was improved after surgery. A longer axial length and older age were correlated with degradation of postoperative visual function.
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Myopic Phakic STAAR Collamer Posterior Chamber Intraocular Lenses for Keratoconus
José F. Alfonso, MD, PhD; Ana Palacios, OD; Robert Montés-Micó, PhD
Submitted: 5/1/07; Accepted: 11/20/07; Posted: 5/15/08In a series of 25 eyes with mild to moderate keratoconus, the STAAR Collamer posterior chamber plate phakic intraocular lens was implanted with 84% of eyes with ±0.50 D manifest spherical equivalent refraction.
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Luis Cadarso, MD; Ana Iglesias, MD; Alberto Ollero, MD; Begońa Pita, MD; Robert Montés-Micó, PhD
Submitted: 2/19/07; Accepted: 1/4/08; Posted: 5/15/08In a series of 20 eyes implanted with the AcrySof Natural IQ aspheric IOL and another 20 eyes with the AcrySof Natural spherical IOL, spherical ocular aberrations postoperatively had values of 0.11 for the IQ group and 0.49 in the Natural group. There was no statistically significant difference in best spectacle-corrected visual acuity between the two groups.
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Matrix-optical Representation of Currently Used Intraocular Lens Power Formulas
Wolfgang Haigis, MS, PhD
Submitted: 9/19/07; Accepted: 1/11/08; Posted: 5/15/08Using matrix optics, the IOL power computed by the SRK/T, Holladay I, Hoffer Q, and Haigis formulas were compared, and power calculations were within approximately 0.30 D of one another.
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Visual Performance After Reduced Blinking in Eyes With Soft Contact Lenses or After LASIK
Ikuko Toda, MD; Atsushi Yoshida, OD; Chikako Sakai, BSc; Yoshiko Hori-Komai, MD; Kazuo Tsubota, MD
Submitted: 5/13/07; Accepted: 1/18/08; Posted: 5/15/08Prolonged eye opening with reduced blinking decreases the quality of vision in eyes wearing soft contact lenses and after LASIK surgery, with more prolonged decrease upon resuming blinking with soft contact lenses than after LASIK.
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Induced Astigmatism With 2.2- and 3.0-mm Coaxial Phacoemulsification Incisions
Samuel Masket, MD; Li Wang, MD, PhD; Shaleen Belani, MD
Submitted: 8/20/07; Accepted: 1/18/08; Posted: 5/15/08Using coaxial phacoemulsification technique, a 3.0-mm incision induced an average of 0.32 D of keratometric astigmatism compared to 0.10 D with a 2.2-mm incision.
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Variability of Higher Order Wavefront Aberrations After Blinks
Krisztina Hagyó, MD; Béla Csákány, MD; Zsolt Lang; János Németh, DSc
Submitted: 1/17/07; Accepted: 1/30/08; Posted: 5/15/08Higher order optical aberrations reached a minimum point with stability about 3 to 5 seconds after a blink-the optimal time to record them.
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W. Matthew Petroll, PhD; R. Wayne Bowman, MD; H. Dwight Cavanagh, MD, PhD; Steven M. Verity, MD; V. Vinod Mootha, MD; James P. McCulley, MD
Submitted: 11/5/07; Accepted: 4/8/08; Posted: 5/15/08Thirty eyes received attenuated steroids after undergoing LASIK with the IntraLase femtosecond laser. Keratocyte activation was found in a large number of eyes, although interface haze was subclinical.
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Multifocal Corneal Ablation for Hyperopic Presbyopes
Seok Won Jung, MD; Min Jung Kim, MS; Shin Hae Park, MD; Choun-Ki Joo MD, PhD
Submitted: 2/21/07; Accepted: 11/7/07; Posted: 4/30/08Using VISX CustomVue system, a corneal profile with a 1.00 diopter near power for presbyopic correction and a paracentral 1.00 diopter near central power for presbyopia correction, and a paracentral correction for distance vision in 54 eyes, the authors demonstrated improved uncorrected distance and near visual acuity with no significant change in higher order aberrations 6 months after surgery in 27 hyperopic patients.
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Fabricio Witzel de Medeiros, MD; Rajiv R. Mohan, PhD; Chikako Suto, MD; Sunilima Sinhá, BA; Vera L. Bonilha, PhD; Shyam S. Chaurasia, PhD; Steven E. Wilson, MD
Submitted: 7/5/07; Accepted: 11/7/07; Posted: 4/30/08In rabbits, there was no difference in clinical haze or the generation of myofibroblasts in the anterior stroma between mechanical removal of the epithelium and removal using 20% ethanol for 30 seconds.
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Seven-year Follow-up of LASIK for Moderate to Severe Myopia
Zhaoqiang Liu, MD, PhD; Yan Li, MD; Zhenying Cheng, MD; Fang Zhou, MD; Hua Jiang, MD; Jinghai Li, MD
Submitted: 1/26/07; Accepted: 11/27/07; Posted: 4/30/08Of an original cohort of 75 consecutive patients, 79% were evaluated at 7 years after LASIK for myopia. Mean refraction remained stable from 1 to 7 years and no progressive late-onset complications occurred.
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Ramon C. Ghanem, MD; Vinicius C. Ghanem, MD; Denise C. de Souza, MD; Newton Kara-José, MD, PhD; Emir A. Ghanem, MD
Submitted: 5/25/07; Accepted: 11/27/07; Posted: 4/30/08In a series of 19 consecutive eyes that previously had radial keratotomy and developed hyperopia, measurements were taken and topography-guided photorefractive keratectomy for hyperopia and astigmatism was done using the MEL-70 platform, with the use of mitomycin C. Preoperative spherical equivalent refraction was +3.80±2.47 D and at 12 months postoperative, it was –3.33±1.96 D.
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Acular LS for Control of Pain Before and During LASIK: A Randomized, Masked Contralateral Eye Trial
Paul J. Dougherty, MD
Submitted: 7/11/07; Accepted: 1/4/08; Posted: 4/30/08Using an ocular pain severity scale of 0 to 6 (extremely painful), and applying Acular LS and artificial tears in a contralateral, masked eye trial before and during surgery, a resultant mean pain score of 0.53 in the Acular LS group and 1.23 in the tears group showed a statistically significant reduction in pain.
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LASIK for Myopia of –9.00 to –17.00 D With the VISX STAR S2: 2- to 5-year Follow-up
Nina Lindbohm, MD, PhD; Ilpo S. Tuisku, MD; Timo M. Tervo, MD, PhD
Submitted: 2/19/07; Accepted: 1/4/08; Posted: 4/30/08LASIK to treat myopia of –9.00 to –17.00 D demonstrated a spherical equivalent refraction postoperatively within 1.00 D for 40% of eyes and 2.00 D for 70%, with high levels of patient satisfaction at 2 to 5 years.
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Bruno M. Fontes, MD; Renato Ambrósio, Jr, MD, PhD; Ruiz S. Alonso, MD; Daniela Jardim, MD; Guillermo C. Velarde, DSc; Walton Nosé, MD
Submitted: 3/15/07; Accepted: 9/19/07; Posted: 4/30/08In a series of 150 consecutive patients, corneal hysteresis increased with corneal thickness and decreased with increasing age.
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A Prospective Bilateral Comparison of Epi-LASIK and LASEK for Myopia
Ahmet Hondur, MD; Kamil Bilgihan, MD; Berati Hasanreisoglu, MD
Submitted: 6/21/07; Accepted: 11/20/07; Posted: 4/15/08In a series of 25 patients, epi-LASIK was done in one and eye and LASEK in the other eye for myopia, with no differences in the postoperative outcomes.
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Ali A. Mearza, FRCOphth; Mohammed Muhtaseb, FRCOphth; Ioannis M. Aslanides, PhD
Submitted: 4/3/07; Accepted: 11/7/07; Posted: 4/15/08A prospective contralateral eye study in 22 patients showed similar refractive and visual acuity outcomes with the WaveLight ALLEGRETTO WAVE Eye-Q and the SCHWIND ESIRIS excimer lasers for myopia and hyperopia.
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Effect of Thin Femtosecond LASIK Flaps on Corneal Sensitivity and Tear Function
Irina S. Barequet, MD; Ami Hirsh, MD; Samuel Levinger, MD
Submitted: 5/13/07; Accepted: 11/7/07; Posted: 4/15/08In a series of 72 myopic eyes undergoing LASIK with an IntraLase femtosecond laser creating an approximately 100-µm thick flap and a Bausch & Lomb excimer laser, therewas minimal change in central corneal sensitivity and tear function over 6 months postoperatively compared to baseline.
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Paul J. Dougherty, MD; Harkaran S. Bains
Submitted: 10/20/06; Accepted: 11/7/07; Posted: 3/31/08In a retrospective comparison of approximately 100 myopic eyes each for the NIDEK scanning-slit, VISX S4 CustomVue, and the Alcon CustomCornea in 2003 demonstrated no differences in refractive or visual acuity outcomes.
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Measurement of LASIK Flap Thickness With Anterior Segment Optical Coherence Tomography
Arthur C.K. Cheng, MRCS, FCOphth(HK); Thomas Ho, MRCOphth; Silvania Lau, BSc; Amy L. Wong, MRCS; Chris Leung, MD; Dennis S.C. Lam, MD, FRCS, FRCOphth
Submitted: 4/5/07; Accepted: 11/7/07; Posted: 3/31/08In a series of 39 eyes undergoing LASIK, intraoperative ultrasound measurement of LASIK flap thickness was significantly thinner than postoperative LASIK flap measurement with OCT.
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Seung Ah Chung, MD; Eung Kweon Kim, MD, PhD; IK Hee Ryu, MD; Jin Kook Kim, MD, PhD; Hyung Keun Lee, MD, PhD
Submitted: 1/15/07; Accepted: 11/7/07; Posted: 3/31/08A series of 204 eyes treated with PRK had immediate postoperative coverage of the cornea with a therapeutic soft contact lens, cultured sheet epidermal allogeneic keratinocytes, or CEAK with amniotic membrane strips. Although the CEAK-covered corneas demonstrated faster epithelial healing, there was no clinically significant difference in patient outcomes among the three groups.
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Comparison of the AcrySof IQ Aspheric Blue Light Filter and the AcrySof SA60AT Intraocular Lenses
Ulrich Mester, MD; Hakan Kaymak, MD
Submitted: 9/5/06; Accepted: 9/5/07; Posted: 3/14/08In a prospective comparison of the spherical AcrySof SA60AT to the aspheric SN60WF demonstrated statistically significantly less total higher order aberrations for a 5-mm pupil in the aspheric lens with a significant reduction in spherical aberration and increased area under the constrast sensitivity curve.
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Arthur C.K. Cheng, MRCS, FCOphth(HK); Thomas Ho, MRCOphth; Srinivas K. Rao, FRCS;
Submitted: 7/25/06; Accepted: 9/7/07; Posted: 3/14/08Using the Orbscan II to measure posterior corneal curvature in 194 eyes before and after myopic LASIK in an area outside of the laser treatment, the peripheral zone shows no difference between preoperative and postoperative values.
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Gerard Sutton, FRANZCO, FRACS, MBBS; Chris Hodge, BAppSc(Orth)
Submitted: 9/26/06; Accepted: 9/12/07; Posted: 3/14/08In a series of 141 eyes using the 30-KHz IntraLase femtosecond laser to make a LASIK flap, 98% of flaps were within 620 µm of intended thickness and 70% were within 610 µm.
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Comparison of the Toric Implantable Collamer Lens and Custom Ablation LASIK for Myopic Astigmatism
Donald R. Sanders, MD, PhD; Monica L. Sanders, BS
Submitted: 3/20/07; Accepted: 9/19/07; Posted: 3/14/08Using United States Food and Drug Administration data, a comparison of the Toric Implantable Collamer Lens with custom ablation LASIK using the VISX and Alcon lasers demonstrated similar refractive outcomes in all groups, ranging from –3.00 to –11.00 diopters at baseline.
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Aleksandar Stojanovic, MD; Ling Wang, MD, MS; Mirko R. Jankov, MD, PhD; Tore A. Nitter, MD, PhD; Qinmei Wang, MD
Submitted: 2/26/07; Accepted: 11/7/07; Posted: 3/14/08Using the WaveLight ALLEGRETTO laser with wavefront optimized ablation in 46 eyes and the Custom-Q ablation in 42 eyes for the treatment of myopia from approximately –1.00 to –8.00 D, the clincial outcomes were the same in both groups, except for a mean postoperative asphericity closer to preoperative values in the Custom-Q group.
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Aylin Ertan, MD; Humeyra Karacal, MD
Submitted: 4/15/07; Accepted: 11/7/07; Posted: 3/14/08In a retrospective series of 133 eyes using the IntraLase femtosecond laser to create a LASIK flap or tunnels for INTACS, mean temporal decentration was approximately 0.60 mm in the LASIK group and 0.79 mm in the INTACS group, as measured by the Pentacam.
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Alejandro Cervińo, OD, PhD, MCOptom; Sarah L. Hosking, BSc(Hns), PhD MCOptom, FAAO, DBO; Robert Montés-Micó, OD, MPhil, PhD
Submitted: 4/29/07; Accepted: 11/7/07; Posted: 3/14/08In a series of 80 myopic eyes measured under non-cycloplegic conditions with a 5-mm pupil, the higher order aberrations reported by the NIDEK OPD-Scan and the Zeiss WASCA aberrometers showed significant differences for specific higher order aberrations, suggesting the instruments cannot be used interchangeably.
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Bao-Gui Wang, MD; Chris P. Lohmann, MD, PhD; Iris Riemann, PhD; Harald Schubert, PhD; Karl-Juergen Halbhuber, MD; Karsten König, PhD
Submitted: 5/4/06; Accepted: 8/13/07; Posted: 1/31/08A solid-state Ti:sapphire femtosecond nanojoule laser created corneal flaps and lenticules in rabbits.
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Comparison of Intacs Treatment Outcomes With Femtosecond Laser in Patients With Keratoconus
Aylin Ertan, MD; Ersel Ozkilic, MD
Submtted: 3/11/07; Accepted: 7/23/07; Posted: 1/15/08In a series of 109 eyes with keratoconus ranging from age 13 to 56 years, Intacs implantation showed no differences in corneal flattening or refractive and visual outcome based on age.
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